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Fantasy Football Defenses to Stream Week 16
Publish Date: December 15, 2025
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One of the biggest strategies in fantasy football is streaming defenses. Each week owners will look at matchups and make waiver wire acquisitions to find their starting defense. Here are fantasy football defenses to stream week 16. (Note: All defenses mentioned are owned in less than 50 percent of ESPN leagues. Stats from before Monday Night Football)
The Bills have had a solid fantasy defense, ranking 10th at 6.7 points per game. They have four double-digit fantasy games this year, which were against the Jets, Panthers, Steelers and Bengals. Their lone negative scoring game was in week 1 against the Baltimore Ravens.
This week, the Bills match up with the Cleveland Browns. The Browns are scoring just 16.1 points per game, which ranks near the bottom of the league. Buffalo will be locked in as they continue to fight for playoff positioning. They are rostered in just 43.7 percent of ESPN leagues.
The Chiefs have a below-average fantasy defense this season, scoring 5.1 points per game and ranking 21st in the league. They have scored double-digit points three times this year, which were in games against the Giants, Raiders and Commanders. They have two negative-scoring outings, which came against the Cowboys and Bills.
In week 16, the Chiefs play the Tennessee Titans. The Titans score 16.1 points per game, which makes them one of the worst offenses in the league. While the Chiefs don’t have the motivation to play for the playoffs, they still have a good defense and can have a successful day. They are rostered in 30.3 percent of ESPN leagues.
Minnesota has an average fantasy defense, ranking 13th in the league at 6.1 points per game. They have scored double-digit points in two games this year, against the Bengals and Commanders. They have scored negative points twice as well, which were against the Chargers and Cowboys.
This week, the Vikings play the New York Giants. The Giants score 21.4 points per game, but could struggle against Brian Flores’s defense, which can be effective against young quarterbacks like Jaxson Dart. The Vikings are rostered in just 38.2 percent of ESPN leagues.
The Falcons have a quality fantasy defense this season, ranking 11th in the league at 6.2 points per game. They have four double-digit performances this season, which were against the Vikings, Bills, Patriots and Saints. Atlanta has one negative-scoring game this year, coming against the Carolina Panthers.